Bed bugs are causing significant concern across several cities in South Carolina. Known for hiding in mattresses, furniture, and walls, these tiny pests feed on human blood and are notoriously hard to eliminate once they establish themselves.
According to pest control data from 2024–2025, five cities in South Carolina are among the most affected by bed bug infestations. This issue is part of a broader trend impacting the southeastern United States, with increasing reports of infestations in homes, hotels, and public spaces.
For residents and visitors alike, especially those traveling to popular destinations such as Charleston, Myrtle Beach, and Greenville, it is crucial to remain vigilant. Bed bugs can spread rapidly and often go unnoticed until the problem becomes severe.
Top 5 South Carolina Cities Affected by Bed Bugs
Greenville
Greenville ranks No. 27 nationwide for bed bug cases, making it the most heavily affected city in South Carolina. Although its national ranking has slightly improved, infestations remain widespread in homes, hotels, and rental properties. Pest control companies in the area report frequent treatments, indicating the issue persists.
Charleston
Charleston’s combination of historic buildings, frequent tourism, and short-term rentals makes it a hotspot for bed bug activity. The city’s unique architecture offers hiding places for pests, while constant visitor traffic contributes to the spread. Both commercial and residential properties continue to report an uptick in infestations.
Myrtle Beach
Myrtle Beach, with its large number of hotels, motels, and resorts, is especially vulnerable. The constant flow of tourists increases the risk of bed bugs being brought in through luggage and clothing. Early detection and consistent inspection are key to managing outbreaks in this popular vacation spot.
Columbia
As the state capital and home to a sizable student population, Columbia deals with bed bugs in shared housing, public facilities, and budget accommodations. Although not as severely affected as Greenville or Charleston, the city still faces notable challenges in managing and preventing infestations.
Florence
Florence has seen a steady rise in bed bug reports, particularly in apartment buildings and public housing units. Though smaller than the other cities on this list, the increase in pest-related concerns has led residents to become more proactive with pest control measures.
Do Health Authorities Help?
In South Carolina, agencies such as the Department of Health and Environmental Control (DHEC) typically do not intervene in bed bug cases in private residences or businesses. Responsibility for treatment falls on property owners or tenants, who are encouraged to seek assistance from licensed pest control professionals.
Staying Safe Amid the Bed Bug Surge
As bed bugs continue to pose problems across South Carolina, those living in or visiting affected cities must take extra precautions. Regular inspections, maintaining cleanliness, and seeking prompt professional help are the best ways to prevent and address infestations.
Although small in size, bed bugs can lead to big issues if left unchecked. Awareness and early action remain the most effective tools in stopping their spread.
